Location matters

For Gene Activation, Location Matters

Location matters: why target location impacts performance in orientation tasks.

This research explores human performance in a spatial orientation task. In three experiments, participants saw a target highlighted in a visual scene and were asked to locate it on a map of the space. Across all of the experiments, the target's location in the visual scene influenced the participants' response times. Generally, response times increased when the target was located farther away f...

Endocytosis of Neurotransmitter Receptors: Location Matters

Endocytosis of excitatory glutamate receptors from the postsynaptic plasma membrane plays a fundamental role in synaptic function and plasticity. In a recent study published in Neuron, Lu et al. (2007) describe protein interactions that link zones of receptor endocytosis directly to the postsynaptic scaffold and propose that local trafficking of receptors facilitated by these endocytic zones is...

Colonic acetate in obesity: location matters!

Gut micro-organisms are recognized as crucial regulators of host immunity and the microbiota has been implicated in several inflammatory, immune, inflammatory or even psychiatric disorders. Therefore the analysis of the complex interactions between gut microbiota and the host is currently under intense investigation. Most of our knowledge stems from the study of animal models while translationa...

Location Matters: Limitations of Global-Scale Datacenters

Common knowledge states that cloud providers will move towards large centralized data centers to achieve economies of scale. However, this centralization presents challenges for certain classes of applications. We describe two of these key challenges – increased response times and regulatory restrictions – and describe how each could be overcome by a larger number of geographically disparate da...